Studies in Mixed Ester Condensations. IV. Acylations with Methyl Dimethoxyacetate1

EE Royals, AG Robinson III

Index: Royals; Robinson Journal of the American Chemical Society, 1956 ,  vol. 78, p. 4161,4162            

Full Text: HTML

Citation Number: 19

Abstract

A study has been made of the Claisen acylation of active hydrogen compounds by means of methyl dimethoxyacetate in the presence of sodium methoxide. A series of six aliphatic methyl esters was subjected to mixed ester condensation with methyl dimethoxyacetate to give the mixed condensation products in yields of 50435%. Basic cleavage of the mixed condensation products gave a-ketoacetals in yields of 73-90%. Acidic cleavage of the a- ...