Endoperoxides as potential antimalarial agents

…, YW Lee, HA Musallam, FI Carroll

Index: Kepler, John A.; Philip, Abraham; Lee, Y. W.; Musallam, H. A.; Carroll, F. Ivy Journal of Medicinal Chemistry, 1987 ,  vol. 30,  # 8  p. 1505 - 1509

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Citation Number: 20

Abstract

A number of mono-and bicyclic endoperoxides were prepared and tested for antimalarial activity in search of a simplified analogue of the 5-oxygen-substituted 1, 2, 4-trioxane ring structure of the naturally occurring antimalarial qinghaosu. The compounds were assayed in an in vitro system for antimalarial activity against chloroquine-susceptible and chloroquine- resistant strains of P. falciparum. The most active compound in this assay was 2-[(( ...