Jatrophane Diterpenes: Preparation of the Western Fragment of Pl??3

C Lentsch, R Fürst, J Mulzer…

Index: Lentsch, Christoph; Fuerst, Rita; Mulzer, Johann; Rinner, Uwe European Journal of Organic Chemistry, 2014 ,  vol. 2014,  # 5  p. 919 - 923

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Citation Number: 2

Abstract

Abstract Jatrophane diterpenes are structurally intriguing natural products with promising biological properties. Herein, the synthesis of the western fragment of the Euphorbiaceae constituent Pl-3 starting from (1R, 5S)-bicyclo [3.2. 0] hept-2-en-6-one is described. Key steps in the sequence include a Baeyer–Villiger oxidation, an iodolactonization reaction, and the installation of the northern side chain through the addition of a lithiated vinyl ...