A total synthesis of (.+-.)-forskolin

S Hashimoto, S Sakata, M Sonegawa…

Index: Hashimoto; Sakata; Sonegawa; Ikegami Journal of the American Chemical Society, 1988 ,  vol. 110,  # 11  p. 3670 - 3672

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Citation Number: 91

Abstract

The labdane diterpene forskolin (l), l isolated from the roots of the Indian herb Coleus forskohlii, has been shown to be a hypotensive agent with spasmolytic, cardiotonic, and platelet aggregation inhibitory activity and also demonstrated to be a unique and potent stimulator of the enzyme adenylate cyclase in various tissues. 2 Owing to its therapeutic potential for gla~ coma,~ congestive heart fail~ re,~ and bronchial asthmaS coupled with a ...