Chemische Berichte

Amination, III. Trimethylsilanol as Leaving Group, V. Silylation—Amination of Hydroxy N??Heterocycles

H Vorbrüggen, K Krolikiewicz

Index: Vorbrueggen, Helmut; Krolikiewicz, Konrad Chemische Berichte, 1984 , vol. 117, # 4 p. 1523 - 1541

Full Text: HTML

Citation Number: 42

Abstract

Abstract Hydroxy N-heterocycles such as 18, 21, 26, and others are efficiently aminated in a one-step/one-pot procedure by silylation-amination to give 20, 23–25 etc. Silylation converts aromatic hydroxy N-heterocycles into activated and lipophilic intermediates of type 3, 8 which react in situ with ammonia, primary or secondary amines to form the corresponding mono-, bis-or tris-aminated products (5, 10). This addition-elimination of amines to O- ...

Related Articles:

A Practical and Easy Synthesis of 2, 4, 6-Trisubstituted-s-triazines

[Herrera, Antonio; Martinez-Alvarez, Roberto; Ramiro, Pedro; Chioua, Mourad; Chioua, Rachid Synthesis, 2004 , # 4 p. 503 - 505]

The umpolung of substituent effect in nucleophilic aromatic substitution. A new approach to the synthesis of N, N-disubstituted melamines (triazine triskelions) under …

[Kolesinska, Beata; Kaminski, Zbigniew J. Tetrahedron, 2009 , vol. 65, # 18 p. 3573 - 3576]

Some Substituted Biguanides and s-Triazines1

[Detweiler; Amstutz Journal of the American Chemical Society, 1952 , vol. 74, p. 1483]

More Articles...