Tetrahedron

Synthesis of (+)-artemisinin and (+)-deoxoartemisinin from arteannuin B and arteannuic acid

DM Nowak, PT Lansbury

Index: Nowak, Deanne M.; Lansbury, Peter T. Tetrahedron, 1998 ,  vol. 54,  # 3-4  p. 319 - 336

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Citation Number: 39

Abstract

(+)-Artemisinin and (+)-Deoxoartemisinin were prepared for the first time from arteannuin B. The synthetic route is short and efficient, making use of the prior art for the final photo- oxygenation/cyclization reaction. A convergent route to each of the above-named products from arteannuic acid is also described. A novel oxidative lactonization reaction was developed for this sequence.