Synthesis and in vitro cytotoxicity of a series of 3-aminoflavones

D Dauzonne, B Folleas, L Martinez…

Index: Dauzonne; Folleas; Martinez; Chabot European Journal of Medicinal Chemistry, 1997 , vol. 32, # 1 p. 71 - 82

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Citation Number: 58

Abstract

To further understand the molecular requirements for the antiproliferative activity of flavonoids, a series of 3-amino-flavones and some of their derivatives were prepared and evaluated using L1210 murine leukemia. Our novel five-step synthetic approach required easily available substituted aromatic aldehydes as starting materials and proved more convenient and more general than previously reported methods. Our results in the 3- ...

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