Tetrahedron

Total synthesis, enzyme-substrate interactions and herbicidal activity of plumbemicin A and B (N-1409)

IA Natchev

Index: Natchev Tetrahedron, 1988 ,  vol. 44,  # 5  p. 1511 - 1522

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Citation Number: 27

Abstract

The unusual natural amino acid 3, 4-didehydro-5-phosphono-D-norvaline, D4, and the cyclic analogue 14 have been synthesized by four-and three-component condensation of the aldehydes 3 and 10, respectively. Strict selectivity has been observed in the enzyme- substrate interactions with the enzymes phosphodiesterase I, alkaline phosphatase, α- chymotrypsin, urease, and alkaline mesintericopeptidase. The tripeptide antibiotics ...