Chemical and pharmaceutical bulletin
Nucleosides. CXLIX. Novel and practical synthesis of. ALPHA.-monofluoro-and. ALPHA.,. ALPHA.-difluorothymidine (F-TDR and F2-TDR).
JM ADAMIC, KA WATANABE
Index: Matulic-Adamic; Watanabe Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 4 p. 1554 - 1557
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Citation Number: 6
Abstract
Di-O-tert-butyldiphenylsilyl (BDPS)-thymidine (2) was converted to α-bromo-3', 5'-di-O-BDPS- thymidine (3) by photobromination. Crude 3 was hydrolyzed to the α-hydroxythymidine derivative 4 which was oxidized with MnO 2 to the 5-formyluracil nucleoside 5. Fluorination