Tetrahedron

Triazolopyridines. Part 9. The synthesis of7-amino (1, 2, 3) triazolo (1, 5-a) pyridines

B Abarca, A Asensio, G Jones, DJ Mouat

Index: Abarca; Asensio; Jones; Mouat Tetrahedron, 1989 ,  vol. 45,  # 22  p. 7041 - 7048

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Citation Number: 7

Abstract

Regiospecific lithiation of (1, 2, 3) triazolo (1, 5-a) pyridines (1) and (4) with subsequent reaction with styryl azide gave small yields of the 7-aminotriazolopyridines (6) and (7). A longer larger scale synthesis of compounds (6) and (7) is described giving overall yields of 17 and 25%, starting from 2-amino-6-methyl (9) or 2-amino-6-ethyl pyridine (19).