Synthesis of 3′-substituted-2′, 3′-dideoxynucleoside analogs as potential anti-AIDS drugs

…, F Frappier, JC Florent, DS Grierson, C Monneret

Index: Maillard, Michel; Faraj, Abdesslem; Frappier, Francois; Florent, Jean-Claude; Grierson, David S.; Monneret, Claude Tetrahedron Letters, 1989 ,  vol. 30,  # 15  p. 1955 - 1958

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Citation Number: 25

Abstract

In cha fight against the human immunodeficlency virus (HIV), the etiological agent of AIDS, tha+ 2nzyme reverse rranscriptase CRT) stands out as a prime target for the development of c~* mnt t! cl-ap* utic agd1, 1 s. Thi:; enzyme ca': alyzi's phosphodiester bond formation during the synthesis of a DNA copy of the viral RNA (reverse transcription), and is not found in the noninfected host