Tetrahedron letters

Practical enantioselective synthesis of lamivudine (3TC™) via a dynamic kinetic resolution

MD Goodyear, ML Hill, JP West, AJ Whitehead

Index: Goodyear, Michael D.; Hill, Malcolm L.; West, Jono P.; Whitehead, Andrew J. Tetrahedron Letters, 2005 , vol. 46, # 49 p. 8535 - 8538

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Citation Number: 17

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A practical enantioselective synthesis of lamivudine 1 is described. A highly effective dynamic kinetic resolution of the 5-hydroxyoxathiolane, followed by chlorination and introduction of cytosine provides an efficient synthesis of lamivudine. ... A practical enantioselective synthesis of lamivudine is ...