Isoxazol??5 (4H) one Derivatives as PTP1B Inhibitors Showing an Anti??Obesity Effect

B Kafle, NG Aher, D Khadka, H Park…

Index: Kafle, Bhooshan; Aher, Nilkanth G.; Khadka, Deegendra; Park, Hwangseo; Cho, Hyeongjin Chemistry - An Asian Journal, 2011 , vol. 6, # 8 p. 2073 - 2079

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Citation Number: 7

Abstract

Abstract In developing inhibitors of therapeutic target enzymes, significant time and effort are committed to the preparation of large numbers of compounds. In an effort to develop a potent inhibitor of protein tyrosine phosphatase (PTP) 1B as an anti-obesity and/or anti-diabetic ...