Clean, reusable and low cost heterogeneous catalyst for amide synthesis

JW Comerford, JH Clark, DJ Macquarrie…

Index: Comerford, James W.; Clark, James H.; MacQuarrie, Duncan J.; Breeden, Simon W. Chemical Communications, 2009 , # 18 p. 2562 - 2564

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Citation Number: 53

Abstract

Although amides are one of the most prevalent functional groups, both in nature 1,2 and in pharmaceuticals, their synthesis is still troublesome. The American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable recently identified amide formation as one of the most utilized and problematic syntheses in the pharmaceutical industry and as such has been labelled as a high priority research area. 3 In particular, attention has been drawn to ...