Medicinal Chemistry Research

Synthesis and antimicrobial activity of new pyridine derivatives-I

NB Patel, SN Agravat, FM Shaikh

Index: Patel, Navin B.; Agravat, Suresh N.; Shaikh, Faiyazalam M. Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 1033 - 1041

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Citation Number: 27

Abstract

Abstract 2-Amino substituted benzothiazoles 2a–l and 2-chloropyridine-3-carboxylic acid 3 were used to prepare 2-[N-(substitutedbenzothiazolyl) amino] pyridine-3-carboxylic acids (4a–l) in 2-ethoxy ethanol. Acid chlorides (5a–l) were condensed with 2-hydroxyethyl piperazine (6) and 2, 3-dichloropiperazine (7) to prepare amide derivatives 2-[N-(substituted benzothiazolyl) amino] pyridin-3-yl (4-(2-hydroxyethyl) piperazin-1-yl) methanones (8a–l) ...

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