Endothelin receptor antagonists: synthesis and structure–activity relationships of substituted benzothiazine-1, 1-dioxides

…, JJ Edmunds, AM Bunker, S Haleen, J Bryant…

Index: Berryman; Edmunds; Bunker; Haleen; Bryant; Welch; Doherty Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1447 - 1456

Full Text: HTML

Citation Number: 18

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The development of benzothiazine-1,1-dioxide derivatives as a new structural class of potent endothelin receptor antagonists is described. Structure–activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ET A receptor subtype. ... In our continuing efforts to design ...

Related Articles:

Facile and regioselective dealkylation of alkyl aryl ethers using niobium (V) pentachloride

[Sudo, Yukinori; Arai, Shigeru; Nishida, Atsushi European Journal of Organic Chemistry, 2006 , # 3 p. 752 - 758]

Efficient Synthesis of Salicylates by Catalytic [3+ 3] Cyclizations of 1, 3-Bis (silyl enol ethers) with 1, 1, 3, 3-Tetramethoxypropane

[Sher, Muhammad; Tam Dang; Ahmed, Zafar; Rashid, Muhammad A.; Fischer, Christine; Langer, Peter Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6284 - 6286]

Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum

[Bioorganic and Medicinal Chemistry, , vol. 14, # 2 p. 334 - 343]

More Articles...