One??Pot Method for Regioselective Bromination and Sequential Carbon–Carbon Bond??Forming Reactions of Allylic Alcohol Derivatives

N Kutsumura, Y Matsubara, K Niwa…

Index: Kutsumura, Noriki; Matsubara, Yusuke; Niwa, Kentaro; Ito, Ai; Saito, Takao European Journal of Organic Chemistry, 2013 , # 16 p. 3337 - 3346

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Abstract

Abstract An efficient one-pot method for the regioselective bromination of allylic alcohol derivatives (two-step reaction sequence) followed by Sonogashira, Negishi, or Suzuki– Miyaura coupling reactions in the same reaction vessel (three-step reaction sequence) has been developed. The key reaction in these one-pot systems is the regioselective DBU- promoted trans HBr elimination of vicinal dibromides bearing an adjacent O-functional ...

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