Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl) cyclohexylamines as high affinity. sigma. receptor ligands. Identification of a new class of …

BR De Costa, WD Bowen, A Thurkauf…

Index: De Costa; Rice; Bowen; Thurkauf; Rothman; Band; Jacobson; Radesca; Contreras; Gray; Daly; Iyengar; Finn; Vazirani; Walker Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3100 - 3110

Full Text: HTML

Citation Number: 39

Abstract

(+)-3-PPP). These compounds showed insignificant affinity for K, dopamine, or PCP receptors, making them valuable tools for the study of u recept0r. s. Furthermore, these compounds also exhibited enantioselectivity ranging from 5-fold for (+)-and (-)-44 to 160-fold for (+)-and (-)-29. Several other compounds showed equivalent selectivity but displayed lower u receptor affinity.

Related Articles:

Synthesis and Pesticidal Properties of Thio and Seleno Analogs of Some Common Urea Herbicides

[Zakrzewski, Jerzy; Krawczyk, Maria Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 7 p. 1880 - 1903]

Reaction under Ball-Milling: Solvent-, Ligand-, and Metal-Free Synthesis of Unsymmetrical Diaryl Chalcogenides

[Zhang, Ze; Wu, Hao-Hao; Tan, Ya-Jun RSC Advances, 2013 , vol. 3, # 38 p. 16940 - 16944]

Structure–Activity Relationships (SAR) Research of Thiourea Derivatives as Dual Inhibitors Targeting both HIV??1 Capsid and Human Cyclophilin A

[Chemical Biology and Drug Design, , vol. 76, # 1 p. 25 - 33]

More Articles...