Enzymatic resolution of (±)-2-endo-hydroxymethyl and acetoxymethyl substituted hexachloronorbornene derivatives

YE Türkmen, İM Akhmedov, C Tanyeli

Index: Tuerkmen, Yunus Emre; Akhmedov, Idris Mecidoglu; Tanyeli, Cihangir Tetrahedron Asymmetry, 2005 , vol. 16, # 13 p. 2315 - 2318

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Citation Number: 8

Abstract

(±)-2-endo-Hydroxymethyl-1, 4, 5, 6, 7, 7-hexachlorobicyclo [2.2. 1] hept-5-ene and (±)-2- endo-acetoxymethyl-1, 4, 5, 6, 7, 7-hexachlorobicyclo [2.2. 1] hept-5-ene were resolved by using various hydrolases to afford enantiomerically enriched products with ees of 94–98%. The absolute configuration was determined by transforming 2-endo-acetoxymethyl-1, 4, 5, 6, 7, 7-hexachlorobicyclo [2.2. 1] hept-5-ene into 2-endo-hydroxymethyl-bicyclo [2.2. 1] hept- ...