Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities

M Abdel-Aziz, GEDA Abuo-Rahma…

Index: Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A.; Hassan, Alaa A. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3480 - 3487

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Citation Number: 183

Abstract

Substituted carboxylic acid hydrazides 1a–d reacted with ethenetetracarbonitril 2 in dimethyl formamide with the formation of diacylhydrazines 4a–d and 5-amino-1-substiuted pyrazole- 3, 3, 4-tricarbonitriles 5a–d. On the other hand, 1a–d reacted with diethyl (E)-2, 3- dicyanobutenedioate 3 to give oxadiazole derivatives 10a–d and pyrazolone derivatives 11a–d, respectively. The prepared compounds 4a–d, 5a–d and 11a–d were evaluated ...

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