Pyrroloisoquinoline antidepressants. 3. A focus on serotonin

…, DF McComsey, MJ Costanzo, SO Nortey

Index: Maryanoff; Vaught; Shank; McComsey; Costanzo; Nortey Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2793 - 2797

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Citation Number: 73

Abstract

A collection of hexahydropyrroloisoquinoline derivatives (1-22), which represent a class of compounds that inhibit the neuronal uptake of dopamine (DA), norepinephrine (NE), and serotonin (5-HT), was investigated in vivo for serotonin-potentiating properties in the mouse head-twitch and rat serotonin syndrome assays. The p-methylthio compound 3b (McN-5652- Z) was found to possess exceptional activity in these assays, and the activity was ...