Synthesis and biological activity of new anti-inflammatory compounds containing the 1, 4-benzodioxine and/or pyrrole system

…, G Rosell, G Daidone, S Plescia, D Schillaci…

Index: Harrak; Rosell; Daidone; Plescia; Schillaci; Pujol Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4876 - 4890

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Citation Number: 65

Abstract

A series of substituted derivatives containing the 1, 4-benzodioxine or pyrrole nucleus are described. All the newly synthesized compounds were examined for their in vitro and in vivo anti-inflammatory activity. Several derivatives, including (S)-2, 14 and 17, showed more anti- inflammatory activity in vivo in these assays (rat paw oedema induced by carrageenan) than the known classical anti-inflammatory agent ibuprofen, whereas other compounds like 1 ...