Molecules

Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands

F Naoum, KM Kasiotis, P Magiatis, SA Haroutounian

Index: Naoum, Fotini; Kasiotis, Konstantinos M.; Magiatis, Prokopios; Haroutounian, Serkos A. Molecules, 2007 , vol. 12, # 7 p. 1259 - 1273

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Citation Number: 19

Abstract

Abstract: Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A- phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα= 5.17 and RBAβ= 3.27). In general, the introduction of a nitro group into the A ring of these ...