Discovery and Development of an Efficient, Scalable, and Robust Route to the Novel CENP-E Inhibitor GSK923295A
R Bellingham, AM Buswell, BM Choudary…
Index: Organic Process Research and Development, , vol. 14, # 5 p. 1254 - 1263
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Abstract
... Organic Process Research & Development. ... was easily managed by controlling the temperature of formation and most specifically during the isolation and drying processes. ... is well-known,(17) and this undesired reactivity is easily remedied by returning to a formal batch process. ...
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[Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J. Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263]