Synthesis and structure-activity relationships of novel 7-substituted 1, 4-dihydro-4-oxo-1-(2-thiazolyl)-1, 8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2

Y Tsuzuki, K Tomita, K Shibamori, Y Sato…

Index: Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575

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Citation Number: 89

Abstract

We have previously reported that a series of 7-substituted 6-fluoro-1, 4-dihydro-4-oxo-1-(2- thiazolyl)-1, 8-naphthyridine-3-carboxylic acids possess moderate cytotoxic activity. In a further attempt to find clinically useful antitumor agents, we investigated the structure-activity relationships (SARs) of a new series of compounds obtained by changing the C-6 position of the fluorine atom in addition to the C-5 and C-7 positions and evaluating their cytotoxic ...