Synthesis of Substituted Coumarins via Brønsted Acid Mediated Condensation of Allenes with Substituted Phenols or Anisoles

S Kim, D Kang, CH Lee, PH Lee

Index: Kim, Sundae; Kang, Dongjin; Lee, Chang-Hee; Lee, Phil Ho Journal of Organic Chemistry, 2012 , vol. 77, # 15 p. 6530 - 6537

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Citation Number: 24

Abstract

Coumarins were obtained from the condensation of electron-rich arenes with allenes in the presence of TfOH in good yield. Depending on the substituent pattern of allenes employed, the general synthetic method of 4-substituted and 3, 4-disubstituted 3-arylcoumarins has been developed. Readily available allenes were employed as the three-carbon atom sources constituting the coumarin skeleton.

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