Toward an understanding of the high enantioselectivity in the osmium-catalyzed asymmetric dihydroxylation (AD). 1. Kinetics

…, PG Andersson, KB Sharpless

Index: Kolb, Hartmuth C.; Andersson, Pher G.; Sharpless, K. Barry Journal of the American Chemical Society, 1994 , vol. 116, # 4 p. 1278 - 1291

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Citation Number: 227

Abstract

Abstract: A systematic study of the relationship between ligand structure and saturation rate constants (k,) in the amine-catalyzed osmylation of terminal olefins was carried out with the aim of learning more about the interactions between the reactants (Le. 0~ 04, the ligand, and the olefin) and of establishing the origin of the large rate accelerations observed with cinchona alkaloid ligands. The results reveal that the saturation rate constants are ...