Palladium-catalyzed carbonylation. A new synthesis of. alpha.-methylene. gamma.-,. delta.-,. epsilon.-lactams and lactones including bicyclic lactams of pyrrolizidine …

…, T Urayama, K Yoshiura, K Chiba, Y Ban

Index: Mori, Miwako; Washioka, Yumiko; Urayama, Takao; Yoshiura, Kagari; Chiba, Katsumi; Ban, Yoshio Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4058 - 4067

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Citation Number: 83

Abstract

The insertion of carbon monoxide into vinyl halides bearing the secondary amine or alcohol with a catalytic amount of Pd (OA& and PPh, was realized to give five-, six-, and seven- membered lactams and lactones carrying a-methylene groups in fairly good yields. Bicyclic heterocycles, pyrrolizidine and indolizidine derivatives, were also synthesized from pyrrolidine and piperidine derivatives possessing vinyl halide groups in the side chain at ...