Tetrahedron

Benzotriazole-assisted synthesis of novel mannich bases from ketones and diverse aldehydes

AR Katritzky, PA Harris

Index: Katritzky, Alan R.; Harris, Philip A. Tetrahedron, 1990 , vol. 46, # 3 p. 987 - 996

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Citation Number: 50

Abstract

A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde.

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