Novel water-soluble anticancer agents derived from 4-arylcoumarins

YB Malysheva, YV Voitovich, EA Sharonova…

Index: Malysheva; Voitovich; Sharonova; Combes; Svirshchevskaya; Vodovozova; Fedorov Russian Chemical Bulletin, 2013 , vol. 62, # 4 p. 1103 - 1110 Izv. Akad. Nauk, Ser. Khim., 2013 , # 4 p. 1102 - 1110,9

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Citation Number: 4

Abstract

Abstract Novel 4-arylcoumarin derivatives were obtained. They are water-soluble analogs of the well-known anticancer drug combretastatin A-4. The key step of the synthesis involves the Suzuki-Miyaura cross-coupling. The water-soluble salts obtained exhibit considerable cytotoxic activity against the HBL-100 and HaCaT cell lines.