Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor

CA Dvorak, H Coate, D Nepomuceno…

Index: Shi, Feng; Shen, Jing Kang; Chen, Danqi; Fog, Karina; Thirstrup, Kenneth; Hentzer, Morten; Karlsson, Jens-Jakob; Menon, Veena; Jones, Kenneth A.; Smith, Kelli E.; Smith, Garrick ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 4 p. 303 - 306

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Abstract

... In searching for exogenous ligands to explore the function of GPR139, Shi et al.(7) have reported on a series of benzohydrazides as potent and selective agonists ... NEt, DCM; (b) 4 M HCl, dioxane; (c) R 1 ArCOCl, Et 3 N, DCM; (d) Boc-NHCH 2 CHO, NaBH(OAc) 3 , DCM; (e) 4 M ...

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