One??Pot synthesis of substituted pyrrolidines via aminomercuration??demercuration of 1, 4??and 1, 5??Hexadiene

J Barluenga, C Nájera, M Yus

Index: Barluenga, J.; Najera, C.; Yus, M. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1297 - 1299

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Citation Number: 23

Abstract

Abstract The aminomercuration-demercuration of 1, 4-and 1, 5-hexadiene yield cis-and trans-2, 5-dimethyl-N-arylpyrrolidines via one-pot process. The intermolecular cyclization reaction goes through the corresponding mercurated pyrrolidines; these intermediates were isolated and characterized when the mercuration reaction was completed. The high stereoselectivity observed allows an easy way of synthesis for N-substituted trans-2, 5- ...