Facile One??Pot Synthesis of N??Alkylated Benzimidazole and Benzotriazole from Carbonyl Compounds

…, Y Zhang, W Wang, J Chen, J Song…

Index: Meng, Xu; Li, Xiaolong; Chen, Wenlin; Zhang, Yuanqing; Wang, Wen; Chen, Jinying; Song, Jinli; Feng, Huijie; Chen, Baohua Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 2 p. 349 - 356

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Abstract

Abstract An efficient one-pot N-alkylation of benzimidazole and benzotriazole from carbonyl compounds and tosylhydrazide has been accomplished via copper powder-catalyzed N—H bond insertion affording N-alkylated products in good yields. The reaction can tolerate a wide range of carbonyl compounds, such as aryl, alkyl, heterocyclic and α, β-unsaturated ketones, and aldehydes.

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