Tetrahedron letters

Practical synthesis of an orally active renin inhibitor aliskiren

H Dong, ZL Zhang, JH Huang, R Ma, SH Chen, G Li

Index: Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340

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Citation Number: 40

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A convergent synthesis of aliskiren was accomplished via the use of Segment AB as the key intermediate, which was prepared via the coupling of the Grignard reagent derived from Segment B with Segment A, followed by subsequent oxidative lactonization. ... Aliskiren (also known as ...

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