Synthesis and evaluation of in vitro anti-tuberculosis activity of N-substituted glycolamides

F Daryaee, F Kobarfard, A Khalaj, P Farnia

Index: Daryaee, Fereidoon; Kobarfard, Farzad; Khalaj, Ali; Farnia, Parisa European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 289 - 295

Full Text: HTML

Citation Number: 13

Abstract

On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2, 2-dimethyl-5- oxo-1, 3-dioxolane) with the proper amines. The minimum inhibitory concentration (MIC) was determined against M. tuberculosis H37Rv in BACTEC 12B medium, using the ...