Synthesis of 2-(2, 3-dimethoxyphenyl)-4-(aminomethyl) imidazole analogues and their binding affinities for dopamine D 2 and D 3 receptors

Y Huang, RR Luedtke, RA Freeman, L Wu…

Index: Huang, Yunsheng; Luedtke, Robert R.; Freeman, Rebekah A.; Wu, Li; Mach, Robert H. Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3113 - 3122

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Citation Number: 19

Abstract

A series of 2-(2, 3-dimethoxyphenyl)-4-(aminomethyl) imidazole derivatives was prepared and their affinity for dopamine D2 and D3 receptors was measured using in vitro binding assays. Several oxadiazole analogues were also prepared and tested for their affinity for dopamine D2 and D3 receptors. The results of receptor binding studies indicated that the incorporation of an imidazole moiety between the phenyl ring and the basic nitrogen did ...