In vitro growth inhibition of human cancer cells by novel honokiol analogs

JM Lin, ASP Gowda, AK Sharma, S Amin

Index: Lin, Jyh Ming; Prakasha Gowda; Sharma, Arun K.; Amin, Shantu Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 10 p. 3202 - 3211

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Citation Number: 22

Abstract

Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells ...

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