Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their …
…, X Wang, X Liang, Y Luo, W Zhu, T Wang…
Index: Ma, Liang; Chen, Jinying; Wang, Xuewei; Liang, Xiaolin; Luo, Youfu; Zhu, Wei; Wang, Tianen; Peng, Ming; Li, Shucai; Jie, Shi; Peng, Aihua; Wei, Yuquan; Chen, Lijuan Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6469 - 6481
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Citation Number: 32
Abstract
Honokiol, widely known as an antitumor agent, has been used as an antiangiogenesis drug lead. In this paper, 47 honokiol analogues and derivatives were investigated for their antiangiogenic activity by application of the transgenic zebrafish screening model, antiproliferative and cytotoxic activity against HUVECs, and three tumor cell lines by MTT assay. 3′, 5-Diallyl-2, 4′-dihydroxy-[1, 1′-biphen-yl]-3, 5′-dicarbaldehyde (8c) was ...
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