Efficient synthesis and structure–activity relationship of honokiol, a neurotrophic biphenyl-type neolignan

…, H Zhai, Y Shimizu, Y Mitsumoto, Y Fukuyama

Index: Esumi, Tomoyuki; Makado, Gouki; Zhai, Haifeng; Shimizu, Yasuhiro; Mitsumoto, Yasuhide; Fukuyama, Yoshiyasu Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2621 - 2625

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Citation Number: 43

Abstract

Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd- catalyzed Suzuki–Miyaura coupling reaction as a key step. Additionally, the structure– activity relationship between neurite outgrowth-promoting activity and its O-methylated ...

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