Synlett

An efficient one-pot synthesis of substituted 2-aminothiophenes via three-component Gewald reaction catalyzed by L-proline

T Wang, XG Huang, J Liu, B Li, JJ Wu, KX Chen…

Index: Wang, Tao; Huang, Xian-Gui; Liu, Jia; Li, Bo; Wu, Jin-Jin; Chen, Kai-Xian; Zhu, Wei-Liang; Xu, Xiao-Yong; Zeng, Bu-Bing Synlett, 2010 , # 9 p. 1351 - 1354

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Citation Number: 31

Abstract

Abstract An efficient one-pot procedure for the direct catalytic synthesis of substituted 2- aminothiophenes catalyzed by l-proline under mild reaction conditions has been developed. A variety of functionalized 2-aminothiophene scaffolds were assembled in high yields by ...