Arzneimittelforschung

Synthesis and bioactivity of 6-phenyl-4, 5-dihydro-3 (2H)-pyridazinone derivatives

T Wang, Y Dong, LC Wang, Z Chen

Index: Wang, Teng; Dong, Ying; Wang, Li-Chen; Chen, Zhen Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 10 p. 641 - 646

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Citation Number: 12

Abstract

Abstract A series of 6-phenyl-4, 5-dihydro-3 (2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1 H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting ...

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