Novel glycine like amino acids from glyco-α-aminonitriles as building blocks for peptide synthesis

H Ducatel, AN Van Nhien, D Postel

Index: Ducatel, Helene; Van Nhien, Albert Nguyen; Postel, Denis Tetrahedron Asymmetry, 2008 , vol. 19, # 1 p. 67 - 81

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Citation Number: 8

Abstract

Our interest in the glycoaminocyanation reaction led us to apply this methodology to introduce amino acids on a monosaccharide using the N-terminal position. The GAAs described in this paper are characterized by having the amino and carboxylic acid functionalities on a disubstituted position of the saccharide backbone leading to α, α- disubstituted glycines. These new sugar amino acids showed a restricted conformation ...