Novel lβ-methylcarbapenems having cyclic sulfonamide moieties: Synthesis and evaluation of in vitro antibacterial activity

…, KH Yoo, D Baek, B Kang, JH Cho, CH Oh

Index: Kim, Seong Jong; Park, Hyeong Beom; Lee, Jae Seoung; Jo, Nam Hyun; Yoo, Kyung Ho; Baek, Daejin; Kang, Byoung-won; Cho, Jung-Hyuck; Oh, Chang-Hyun European Journal of Medicinal Chemistry, 2007 , vol. 42, # 9 p. 1176 - 1183

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Citation Number: 19

Abstract

The synthesis of a new series of 1β-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram- negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1, 2, 6] thiadiazinan-1, 1-dioxide moiety showed the most potent antibacterial activity.

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