Novel piperidine. sigma. receptor ligands as potential antipsychotic drugs

…, S Drummond, AL Johnson, AA Kergaye…

Index: Gilligan; Cain; Christos; Cook; Drummond; Johnson; Kergaye; McElroy; Rohrbach; Schmidt; Tam Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4344 - 4361

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Citation Number: 71

Abstract

u receptor ligands represent a new class of potential antipsychotic drugs. This paper presents the structure-activity relationships leading to novel disubstituted piperidine u ligands, which have little or no affinity for dopamine D2 receptors. Selectivity for u sites over dopamine D2 or serotonin 5-HTz receptors appears to be governed by the chemical nature of the piperidine nitrogen substituent, its distance from the basic nitrogen, and its ...