4 (1 H)-Quinolinones by a tandem reduction-addition-elimination reaction

RA Bunce, B Nammalwar

Index: Bunce, Richard A.; Nammalwar, Baskar Organic Preparations and Procedures International, 2010 , vol. 42, # 6 p. 557 - 563

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Citation Number: 12

Abstract

Compounds incorporating the 4 (1H)-quinolinone ring system are commonly found in drug chemistry and express a broad spectrum of biological activities. 1–13 Thus, they have become attractive targets for synthesis. In this paper, we report simple and efficient syntheses of 4 (1H)-quinolinone (3), 2, 4 (1H, 3H)-quinolinedione (8) and ethyl 1, 4-dihydro- 4-oxo-3-quinolinecarboxylate (10) using an adaptation of the Leimgruber-Batcho indole ...

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