Microwave-mediated synthesis of an arylboronate library

J Spencer, CB Baltus, H Patel, NJ Press…

Index: Spencer, John; Baltus, Christine B.; Patel, Hiren; Press, Neil J.; Callear, Samantha K.; Male, Louise; Coles, Simon J. ACS Combinatorial Science, 2011 , vol. 13, # 1 p. 24 - 31

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Citation Number: 15

Abstract

A series of arylboronates has been synthesized from the reaction of 2-(2-,(3-, or (4- (bromomethyl) phenyl)-4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolane 1 {1− 3} respectively with a range of N-, S-, and O-nucleophiles, using microwave-mediated chemistry. For the synthesis of N-and S-substituted boronates, a supported base, PS-NMM, was employed, and many reactions were complete within 15 min. With O-nucleophiles, a mixture of ...