3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization

P Pevarello, MG Brasca, P Orsini…

Index: Ohta, Shunsaku; Sano, Atsunori; Yamashita, Masayuki; Okamoto, Masao Heterocycles, 1993 , vol. 36, # 4 p. 743 - 749

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Abstract

... Volume: Page: ... lead optimization process brought us to the discovery of (2S)-N-(5-cyclopropyl- 1H-pyrazol-3-yl)-2-[4-(2-oxo ... 1 PNU-292137 (Chart 1) was identified as a compound suitable for in vivo evaluation but also endowed with suboptimal physicochemical ...

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