Tetrahedron letters

Microwave-assisted, Mo (CO) 6-mediated, palladium-catalyzed amino-carbonylation of aryl halides using allylamine: from exploration to scale-up

P Appukkuttan, L Axelsson, E Van der Eycken…

Index: Appukkuttan, Prasad; Axelsson, Linda; der Eycken, Erik Van; Larhed, Mats Tetrahedron Letters, 2008 , vol. 49, # 39 p. 5625 - 5628

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Citation Number: 30

Abstract

Palladium-catalyzed aminocarbonylations of various (hetero) aryl halides with allylamine using Mo (CO) 6 as a solid, in situ CO source, were explored. Microwave-enhanced conditions proved to be highly useful in promoting the conversions in a mere 10–20min with various (hetero) aryl iodides, bromides and chlorides. The scale-up of a microwave- enhanced aminocarbonylation to 25mmol scale was performed successfully.

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