Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents

R Csuk, S Albert, B Siewert, S Schwarz

Index: Csuk, Rene; Albert, Sabrina; Siewert, Bianka; Schwarz, Stefan European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 669 - 678

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Citation Number: 14

Abstract

Several new (E) stilbenes were synthesized by a combination of a Wittig olefination followed by Mizoroki–Heck coupling reactions. These compounds were screened for antitumor activity in a panel of 8 human cancer cell lines by a colorimetric SRB assay. Several of these compounds exhibit strong cytotoxicity. The most active compound of this series showed an average IC50 value of 0.03 μmol; it acts by apoptosis as shown by a dye-exclusion test, an ...

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