Synthesis of resveratrol using a direct decarbonylative Heck approach from resorcylic acid
MB Andrus, J Liu, EL Meredith, E Nartey
Index: Andrus, Merritt B.; Liu, Jing; Meredith, Erik L.; Nartey, Edward Tetrahedron Letters, 2003 , vol. 44, # 26 p. 4819 - 4822
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Citation Number: 92
Abstract
The phytoalexin resveratrol has been made using a decarbonylative Heck reaction. The acid chloride derived from 3, 5-dihydroxybenzoic acid was coupled with 4-acetoxystyrene in the presence of palladium acetate and N, N-bis-(2, 6-diisopropylphenyl) dihydroimidazolium chloride to give the substituted stilbene in 73% yield as the key step.
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